Role of androgen receptor in sex dependent and independent manner

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461389
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: The University of Tokushima
• Principal Investigator: AIHARA Ken-ichi 徳島大学, 大学院医歯薬学研究部, 特任教授 (70372711)
• Co-Investigator(Kenkyū-buntansha): IKEDA Yasumasa 徳島大学, 大学院医歯薬学研究部, 准教授 (60432754) ; YAGI Shusuke 徳島大学, 大学院医歯薬学研究部, 助教 (00507650)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アンドロゲン受容体 / アンジオテンシンII / ApoE / 心筋肥大 / 動脈硬化 / マクロファージ

Outline of Final Research Achievements

Not only menopause but also andropause are critical issue to prevent the development of cardiovascular diseases in elderly people. In order to clarify the physiological role of androgen receptor (AR) in the process of cardiovascular remodeling, we studied mouse models of angiotensin II-infused female AR-deficient mice and macrophage-specific male AR-deficient mice. The values of cardiac hypertrophy and left ventricular interstitial fibrosis area showed no difference between the angiotensin II-infused female AR-deficient mice and wild type mice. In contrast, aortic adventitia hyperplasia was attenuated in AR-deficient female mice. In addition, macrophage specific AR-deficient male mice did not show the acceleration of atherosclerotic plaque area. Therefore, AR in macrophage was not associated with the development of atherosclerosis.

Free Research Field

内分泌代謝