2015 Fiscal Year Final Research Report
Investigation of mechanisms of aldosterone-induced resistant hypertension in life style-related diseases
| Project/Area Number |
25461397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アルドステロン / 糖尿病 / ミネラルコルチコイド受容体 |
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| Outline of Final Research Achievements |
Chronic hyperglycemia results in multiple vascular complications in diabetes mellitus; however, the precise mechanisms are unknown. The present study showed that hyperglycemia induces O-linked N-acetylglucosamine (O-GlcNAc) modification of mineralocorticoid receptor (MR) at the N-terminus, which is followed by elevation of MR protein levels due to inhibition of the ubiquitin-proteaosme pathway-mediated protein degradation, thus resulting in MR transactivation. The pathological MR stabilization may be involved in renal dysfunction in type 2 diabetes mellitus.
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| Free Research Field |
内分泌代謝学
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