Analysis of physiological and pathological function of BMP-3b acts as novel adipocytokine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Hino Jun 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40260351)
• Co-Investigator(Kenkyū-buntansha): MIYAZATO Mikiya 国立循環器病研究センター, 研究所, 部長 (50291183) ; ARAI Yuji 国立循環器病研究センター, 研究所, 室長 (30202724)
• Co-Investigator(Renkei-kenkyūsha): KANGAWA Kenji 国立循環器病研究センター, 研究所, 所長 (00112417)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肥満 / ＢＭＰ-3ｂ / 脂肪細胞 / エネルギー消費 / PPARγ

Outline of Final Research Achievements

Although BMP-3b is highly expressed in adipose tissues, its functions were yet to be clarified. We showed that BMP-3b inhibited adipogenesis in cultured adipocytes. We generated adipose tissue specific BMP-3b transgenic mice (Tg) to examine BMP-3b functions in vivo. Tg mice exibited anti-obesity effect and increased energy expenditure. We found that PPARγ and its target gene fatty acid translocase (FAT/CD36) were suppressed in Tg mice, indicating that suppression of translocation of fatty acid into adipocytes leaded to prevention of obesity. We also showed that enhanced BAT function and locomoter activity, which might cause increased energy expenditure.

Free Research Field

内分泌・代謝