2015 Fiscal Year Final Research Report
Analyzing the mechanism of TKI-resistance in Ph-positive ALL
Project/Area Number |
25461404
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Hokkaido University |
Principal Investigator |
KONDO TAKESHI 北海道大学, 医学(系)研究科(研究院), 講師 (70333606)
|
Co-Investigator(Kenkyū-buntansha) |
OHBA Yusuke 北海道大学, 大学院医学研究科, 教授 (30333503)
|
Co-Investigator(Renkei-kenkyūsha) |
MINAMI YOSUKE 神戸大学, 医学部附属病院, 講師 (60513752)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | BCR-ABL / TKI / Ph+ALL |
Outline of Final Research Achievements |
Using the FRET-based drug sensitivity test, we identified and isolated TKI-rafractory cell population in Ph-positive ALL. Analysis of gene expression profile in TKI-refractory cells indicated that so many intracellular pathways were activated. One of them was sumoylation pathway. In vitro analysis, we proved that BCR-ABL is sumoylated. Moreover, inhibition of sumoylation effectively induced apoptosis in Ph+ALL cells.
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Free Research Field |
血液内科学
|