Identification of microRNAs that might be therapeutic target of malignant lymphomas

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461405
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Akita University
• Principal Investigator: Tagawa Hiroyuki 秋田大学, 医学(系)研究科(研究院), 講師 (30373492)
• Co-Investigator(Kenkyū-buntansha): Tagawa Hiroyuki 秋田大学, 大学院医学系研究科, 講師 (30373492) ; Takahashi Naoto 秋田大学, 大学院医学系研究科, 教授 (80344753)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: miRNA / malignant lymphoma / CTCL / Side population / miR-16 / miR-150 / CCR6 / metastasis

Outline of Final Research Achievements

In this study we scheduled following two purposes. (1) To identify specific miRNAs that may be associated with invasion and metastasis of CTCL, and (2) to Identify of specific miRNAs that is specifically regulated in side population of mantle cell lymphoma.
(1). In the presence of continuous CCR6 upregulation accompanied by miR-150 downregulation, IL-22 activation leads to continuous CCL20-CCR6 interaction in CTCL cells and, in turn, autocrine metastasis to distal organs Ito et al., 2014 Blood; Ikeda et al., 2016 Oncotarget).
(2). We found that Bmi-1 was over expressed in side population (SP) cells of relapsed MCL, ant its up regulation by miR-16 was deeply associated with MCL tumorigenesis via enhancing anti-apoptotic function (Teshima et al., 2014 Oncogene).

Free Research Field

miRNA and malignant lymphomas