2015 Fiscal Year Final Research Report
Identification of therapeutic candidate targets specifically expressed in myeloma side population cells
| Project/Area Number |
25461406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Akita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAGAWA Hiroyuki 秋田大学, 医学系研究科, 講師 (30373492)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 多発性骨髄腫 / SP細胞 / 遺伝子発現 |
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| Outline of Final Research Achievements |
We conducted comparison of miRNA/gene expression between SP and non-SP cells in multiple myeloma. We found that SP showed stem cell like phenotypes. We purified SP cells from myeloma cell lines and detected that miR-181 family’s downregulation in SP cells. Moreover we found that Bmi-1 is a possible target of miR-181, and finally revealed following mechanism: EZH2 activation->miR-181 downregulation->downregulation of Bim or Pten->Bcle downregulation MM cells.
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| Free Research Field |
血液内科学
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