2015 Fiscal Year Final Research Report
Epigenetic mechanisms of development of follicular helper-T like tumors
| Project/Area Number |
25461407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | lymphoma / RHOA / TET2 |
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| Outline of Final Research Achievements |
Angioimmunoblastic T-cell lymphoma (AITL) is a hematologic malignancy. AITL tumor cells have features of follicular helper T cells. Loss-of-function mutations in TET2, encoding an epigenetic regulator, are frequently found in AITL samples. We clarified mechanisms of AITL development using a lymphoma model in Tet2 gene-trap mice, and genomic analysis of human AITL. TET2 gene-trap mice developed lymphoma having features of follicular helper T cells, accompanying hypermehtylation of silencer of Bcl6. We also identified RHOA mutations as well as TET2 mutations in 70% of AITL samples.
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| Free Research Field |
血液がんの発症メカニズム
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