2015 Fiscal Year Final Research Report
The clalification of the mechanism of B-cell lymphoma progression with post-transcriptional factor, TFL.
| Project/Area Number |
25461421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
Minagawa Kentaro 神戸大学, 医学(系)研究科(研究院), 研究員 (80432574)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ＴＦＬ / 転写後調節 / リンパ腫 / ｍＲＮＡ |
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| Outline of Final Research Achievements |
We found the post-transcriptional factor, TFL, from a lymphoma patient. TFL modulates many cytokines after inflammation to localize its inflammatory effect. We found TFL deficient mice are prone to have worse prognosis in lymphoma induced mice. Further we found a certain molecule was abnormally controlled without TFL. In clinical setting, the deficit of TFL are worse prognosis in diffuse large B-cell lymphoma. It is of interest whether TFL would be the reliable and effective prognosis marker for B-cell lymphoma.
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| Free Research Field |
血液内科
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