2015 Fiscal Year Final Research Report
Identification and control of factors which regulate CML stem cells
| Project/Area Number |
25461425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kubota Yasuhi 佐賀大学, 医学部, 講師 (60570413)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 白血病 / 幹細胞 / 低酸素 / シクロデキストリン / BMI-1 / HIF-1α |
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| Outline of Final Research Achievements |
We reported that higher expression of HIF-1alpha became a trigger of lymphoma. In addition, we reported that cyclodextrin and BIM-1 inhibitor showed higher efficacy against leukemic stem cells than normal hematopoietic stem cells and these compounds were promising candidates for novel agents for hematological malignancies. We made it clear that hypoxemia was closely related to hematological malignancies and novel agents which targeted for hypoxemia were very important.
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| Free Research Field |
血液内科学
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