Novel strategy against GVHD using NB-UVB with expansion of Treg cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Sapporo Medical University
• Principal Investigator: Sato Tsutomu 札幌医科大学, 医学部, 講師 (40404602)
• Co-Investigator(Kenkyū-buntansha): Iyama Satoshi 札幌医科大学, 医学部, 助教 (50398319)
• Co-Investigator(Renkei-kenkyūsha): Kawano Yutaka 札幌医科大学, 医学部, 助教 (80398320)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: GVHD / NB-UVB

Outline of Final Research Achievements

Narrowband ultraviolet B (NB-UVB) has been widely used in dermatological phototherapy. As for the application of NB-UVB phototherapy to GVHD, we previously reported that it was highly efficacious for cutaneous lesions of acute GVHD (aGVHD) and that expansion of regulatory T (Treg) cells induced by NB-UVB might be one of the mechanisms. In order to examine whether NB-UVB irradiation through expansion of Treg cells is effective for the treatment of not only cutaneous aGVHD but also aGVHD of inner organs such as the intestine or liver, we conducted experiments in which a murine lethal aGVHD model, characterized by severe involvement of the intestine, were irradiated with NB-UVB. We found that NB-UVB irradiation improved the clinical score and survival rate. The numbers of infiltrating Treg cells in inflamed tissue of the intestine and those in spleen were increased in mice treated with NB-UVB.

Free Research Field

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