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2015 Fiscal Year Final Research Report

Identifing novel therapeutic target molecules in multiple myeloma using BCL9-ChIPSeq

Research Project

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Project/Area Number 25461430
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSapporo Medical University

Principal Investigator

Takada Kohichi  札幌医科大学, 医学部, 助教 (90398321)

Co-Investigator(Kenkyū-buntansha) KAMIHARA YUSUKE  札幌医科大学, 医学部, 研究員 (10624421)
KATO JUNJI  札幌医科大学, 医学部, 教授 (20244345)
KOBUNE MASAYOSHI  札幌医科大学, 医学部, 准教授 (90336389)
Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsBCL9
Outline of Final Research Achievements

Multiple myeloma (MM) is characterized by clonal proliferation of long-lived plasma cells within the bone marrow. Despite recent advances in its treatment, MM remains an incurable disease, underlining the need to continue exploring its molecular characteristics. We have identified that BCL9 has a pivotal role in MM pathogenesis. In this study, we found that CYBRD1, which is a iron regulating molecule, as a novel therapeutic target in MM using BCL9-Chromatin Immunoprecipitation (ChIP)-Sequence (Seq) (ChIPSeq).

Free Research Field

多発性骨髄腫

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Published: 2017-05-10  

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