2015 Fiscal Year Final Research Report
Animal models and hemostatic pathophysiology of acquired von Willebrand syndrome (AvWS)
| Project/Area Number |
25461445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA KYOUSUKE 名古屋大学, 医学部附属病院, 講師 (70444403)
SUZUKI NOBUAKI 名古屋大学, 医学部附属病院, 助教 (70637686)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | von Willebrand因子 / von Willebrand病 / AvWS / 血友病 |
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| Outline of Final Research Achievements |
Acquired von Willebrand Syndrome (AvWS) has a unique bleeding symptom, that has not been observed in other hemostatic disorders. This study had a strategic approach to establish AvWS animal models and aimed to unveil the specific mechanisms underlining the development of AvWS bleeding diathesis. Our recent clinical observation indicated that activation of extrinsic pathways had some potential in controlling bleeding in patients with AvWS. We therefore observed the unique pattern of thrombin generation assay and ROTEM (Rotation thromboelastgram) assays to enable the novel therapeutic approach to this disorder.
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| Free Research Field |
血栓止血学
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