2015 Fiscal Year Final Research Report
Analysis of the roles of anti-apoptotic molecule, Anamorsin in immune cells
| Project/Area Number |
25461449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 大学院医学系研究科, 教授 (20177489)
ORITANI Kenji 大阪大学, 大学院医学系研究科, 准教授 (70324762)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アナモルシン / Bリンパ球 / 遺伝子改変マウス / 鉄・硫黄クラスター / 鉄代謝 |
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| Outline of Final Research Achievements |
In this study, we have analyzed the functions of Anamorsin (AM), anti-apoptotic molecule, in the immune cells, especially in B lymphocytes by using gene-altered mice (both of AM transgenic mice and AM conditional knock-out mice). The overexpression of AM in B lymphocytes leads to inhibition of Ras activity and decrease of the signaling with LPS stimulation. The defect of AM in B lymphocytes leads to inhibition of B lymphocyte terminal differentiation. From these data, AM might play important roles on the signaling pathways in B lymphocytes.
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| Free Research Field |
血液内科
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