2016 Fiscal Year Final Research Report
Development of novel therapeutic strategy for acute GVHD using IL-21 signal blockade
| Project/Area Number |
25461459
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
oh iekuni 自治医科大学, 医学部, 講師 (20398514)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | IL-21 |
|---|
| Outline of Final Research Achievements |
Over the past several years, some studies have been made on relationship between GVHD and IL-21 by using experimental mouse GVHD model. From these animal studies, blocking the IL-21 signaling after bone marrow transplantation can attenuate GVHD without compromising the GVL effect. IL-21 signal blockade may be an ideal therapeutic target molecule to treat GVHD. Near future, when anti-human IL-21 neutralizing antibody that can be administered to human are developed, they can be used as antibody drugs like tocilizumab and infliximab already used for the treatment of rheumatoid arthritis.
|
| Free Research Field |
移植片対宿主病
|
