2015 Fiscal Year Final Research Report
Role of lysophosphatidylserine-producing enzyme (PS-PLA1) in the pathogenesis of SLE and further applications as SLE biomarker
| Project/Area Number |
25461487
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 全身性エリテマトーデス |
|---|
| Outline of Final Research Achievements |
We determined the serum levels of lysophosphatidic acid-producing enzyme (ATX) and lysophosphatidylserine-producing enzyme (PS-PLA1) to clarify the role of the lysophospholipid in the pathophysiology SLE. The serum level of PS-PLA1 was significantly higher in SLE patients, and correlated with some of the SLE disease activity indices. In pristine-induced mouse SLE model, PS-PLA1 positive cells were more frequently detected in spleen. T cell stimulation led to the increase of PS-PLA1 expression and decrease of LPS receptor expression. High concentration of IFN-α increased the PS-PLA1 expression in peripheral blood mononuclear cells. Therefore, PS-PLA1 is considered to be a T-cell activation marker as well as a member of IFN-α signatures.
|
| Free Research Field |
内科学
|
