2016 Fiscal Year Final Research Report
IgG4-related disease can cause MALT lymphoma
| Project/Area Number |
25461496
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Niigata University |
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Principal Investigator |
Takizawa Jun 新潟大学, 医歯学系, 准教授 (70463990)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | MALTリンパ腫 / IgG4関連疾患 / 眼窩MALTリンパ腫 / 肺MALTリンパ腫 / リンパ形質細胞性リンパ腫 / MYD88変異 / MALT1遺伝子 |
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| Outline of Final Research Achievements |
Recently some cases with MALT lymphoma arising from IgG4-related disease (IgG4-RD) were reported. To assess the association between MALT lymphoma and IgG4-RD, 69 patients with MALT lymphoma diagnosed in our hospital were examined. Of the 69 cases of MALT lymphoma, 11 (16 %) had IgG4-related disease by comprehensive diagnostic criteria for IgG4-RD. Orbita was the most frequently involved site (10 cases), followed by lung (one case). Three cases with orbital MALT lymphoma associated with IgG4-RD occurred second lymphoid neoplasms with different sites and clones, suggesting chronic inflammation produced by IgG4-RD can promote the development of lymphoid malignancies such as MALT lymphoma.
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| Free Research Field |
血液内科学
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