Metabolomics-based molecular phenotyping of severe asthma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Tokai University
• Principal Investigator: ASANO Koichiro 東海大学, 医学部, 教授 (60192944)
• Co-Investigator(Kenkyū-buntansha): ABE Tadashi 東海大学, 医学部内科学系呼吸器内科学, 教授 (80129311)
• Co-Investigator(Renkei-kenkyūsha): FUKUNAGA Koichi 慶應義塾大学, 医学部呼吸器内科, 講師 (60327517) ; NAGAOKA Takashi 早稲田大学, 理工学術院, 講師 (00367054) ; ARITA Makoto 東京大学, 薬学研究科, 准教授 (80292952)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 重症喘息 / バイオマーカー / メタボロミクス

Outline of Final Research Achievements

Cluster analyses using clinical parameters have identified several phenotypes of severe asthma, including early-onset allergic phenotype and later-onset eosinophilic phenotype. In the present study, we aimed to clarify molecular phenotypes of severe asthma using motabolomic approach.
We have identified that the levels of volatile organic compounds including benzene, xylene, and nonan in exhaled air of the patients with severe asthma were increased. In addition, serum levels of periostin were increased in a subpopulation of patients with severe asthma, who exhibited later-onset, non-atopic eosinophilic disease often accompanied with eosinophilic rhinosinusitis with nasal polyps. In conclusion, we were able to identify several non-invasive biomarkers that reflect either the severity or the phenotype of asthma.

Free Research Field

呼吸器内科学