2016 Fiscal Year Final Research Report
Regulation of mast cell activation by competitive inhibition of FceRI assembly
| Project/Area Number |
25461505
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Saga University (2015-2016)
Nihon University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | マスト細胞 / 高親和性IgE受容体 / SS結合 |
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| Outline of Final Research Achievements |
Previous studies have shown that disulfide-linked homodimerization of FcRγ-chains is important for mast cell activation via the FcεRI complex. However, the biological significances of the disulfide-linked FcRγ dimerization in the FcεRI-mediated mast cell activation are largely unknown. In this study, we revealed for the first time that, in murine mast cell, FcRγ dimerization through the Cys7 residue is a crucial process for controlling degranulation and cytokine production, depending on the strength of FcεRI stimulation. In addition, we showed that the FcRγ dimerization enhances the stability of FcεRI complex in the presence of strong detergents. Our findings of the present study could deepen our understanding of mast cells activation process.
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| Free Research Field |
アレルギー学
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