2015 Fiscal Year Final Research Report
Clinical importance of anti interferon-gamma autoantibodies
| Project/Area Number |
25461507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI TAKURO 新潟大学, 医歯学系, 助教 (00444159)
TANABE YOSHINARI 新潟大学, 医歯学総合病院, 准教授 (40444161)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 播種性非結核性抗酸菌症 / 抗インターフェロンガンマ抗体 / 中和能 / 日和見感染症 |
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| Outline of Final Research Achievements |
In the recent years, we have an increasing trend non- tuberculous mycobacterial disease around the world. Anti-interferon gamma autoantibodies were often found in formerly healthy patients with disseminated NTM infections. In this study we intend to establish the measurement method of the autoantibodies in clinical specimens from patients.
We have developed the method to evaluate the neutralizing capacity to interferon-gamma of sera and to quantify the relative concentrations of the autoantibodies. Twenty-six antibody-positive cases were observed so far and also clarified their clinical characteristics. Antibody titer in response to the disease of non- tuberculous mycobacterial disease tend to increase or decrease , it is also useful as a marker to reflect the disease has been suggested .
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| Free Research Field |
呼吸器内科学、感染症学
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