The development of the controlling system for innate immune activity: a new treatment development of refractory granuloma formation disease.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461511
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Yamaguchi University
• Principal Investigator: TANABE Tsuyoshi 山口大学, 医学(系)研究科(研究院), 教授 (80260678)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Natsu 山口大学, 大学院医学系研究科, 助教 (40450671)
• Co-Investigator(Renkei-kenkyūsha): EISHI Yoshinobu 東京医科歯科大学, 病理学, 教授 (70151959)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 自然免疫 / 肉芽腫形成疾患 / インフラマソーム

Outline of Final Research Achievements

We revealed an association between sarcoidosis onset and genetic polymorphism of the inflammasome, innate immunity factor complex (NLRP1, NLRP2, NLRP3). We claridied the association between the change of clinical symptoms and expression change in the developmental stage of following factors ; inflammasome factors involved in the pathogenesis of granuloma formation disease (NLRP3, NLRP1, ASC, Caspase-1), innate immune factor TLR4, anti-oxidation factor (Catalase, Heme-oxygenase). Catalase protein of P. acnes was revealed to induce Th1 immune response in sarcoidosis patients. We also clarified that the infection of P. acnes participated in the onset of prostate cancer.

Free Research Field

分子予防医学