2015 Fiscal Year Final Research Report
An analysis of miRNA related host-microbial crosstalk
| Project/Area Number |
25461520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINO Yoshihiko 国立感染症研究所, ハンセン病研究センター 感染制御部, 室長 (20569694)
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| Research Collaborator |
NISHIMURA Tomoyasu 慶應義塾大学, 保健管理センター(日吉), 講師 (90348649)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 感染症 |
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| Outline of Final Research Achievements |
To figure out the pathophysiology and find biomarkers reflecting disease activity and new therapeutic targets for Mycobacterium avium complex (MAC) pulmonary disease, which is an intractable chronic respiratory infection, we searched micro RNAs (miRNAs) associated with MAC pulmonary disease.
By comparing the profile of serum miRNAs of the patients with that of healthy controls, we determined hsa-miR-346 as a miRNA associated with MAC pulmonary disease. We will evaluate whether this miRNA is a biomarker reflecting disease activity and perform further studies to figure out the pathophysiology of MAC pulmonary disease associated with hsa-miR-346 for novel treatment.
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| Free Research Field |
感染症内科
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