Gonadal function and fertility preservation of childhood cancer survivor

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461544
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: MIYOSHI YOKO 大阪大学, 医学系研究科, 講師 (40457023)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 妊孕性温存 / 小児がん / 小児がん経験者 / 晩期合併症 / 性線機能 / 妊孕性

Outline of Final Research Achievements

Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. We have reported the endocrinological abnormalities and gonadal dysfunction of among childhood cancer survivors (CCSs). We have displayed that the serum concentration of anti-Mullerian hormone (AMH) concentration was a useful marker of ovarian reserve in CCSs. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. The different patterns in the recovery phase demonstrated that the AMH levels just immediately after the end of cancer therapy is inappropriate for the evaluation of the ovarian reserve.

Free Research Field

小児内分泌学