High mobility group box 1 enhanced febrile seizures and acquired epilepsy in a rodent model of infantile febrile seizures

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461553
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Ehime University
• Principal Investigator: Fukuda Mitsumasa 愛媛大学, 医学部附属病院, 准教授 (80274330)
• Co-Investigator(Kenkyū-buntansha): Suzuki Yuka 愛媛大学, 大学院医学系研究科, 寄附講座准教授 (00304634) ; Tanaka Junya 愛媛大学, 大学院医学系研究科, 教授 (70217040)
• Co-Investigator(Renkei-kenkyūsha): Ishizaki Yoshito 九州大学, 大学病院, 助教 (20572944)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 熱性痙攣 / 側頭葉てんかん / HMGB－１ / 分子標的 / ラット / 海馬 / 脳波 / アストログリア

Outline of Final Research Achievements

We investigated the role of HMGB1 in febrile seizures (FS) and secondary acquired epilepsy associated with febrile status epilepticus using hyperthermia-induced seizures (HS) in immature rats, a model of human FS. HMGB1 enhanced HS, but did not induce any hippocampal damage. HMGB1 also enhanced acquired epilepsy after febrile status epilepticus using hyperthermia-induced seizures (HS), and histological analysis showed that astrocytes were significantly increased in the hippocampus and the corpus callosum in rats having acquired epilepsy. Our results indicate that infantile prolonged febrile seizures with HMGB1 overproduction could enhance adulthood epileptogenesis and might contribute to the development of mesial temporal lobe epilepsy. Further, astrogliosis also should play an important role in acquired epileptogenesis.

Free Research Field

小児科学、小児神経学、てんかん学