2015 Fiscal Year Final Research Report
Growth and energy metabolism in Mfsd2 gene knockout mouse
| Project/Area Number |
25461556
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORITAKE HIROSHI 宮崎大学, 医学部生殖発達医学講座小児科学分野, 准教授 (40336300)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
DATE YUKARI 宮崎大学フロンティア科学実験総合センター, 生理活性物質研究部門・生理活性物質機能解析分野, 教授 (70381100)
AKIEDA SAYAKA 宮崎大学フロンティア科学実験総合センター, 生理活性物質研究部門・生理活性物質機能解析分野, 准教授 (20549076)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | Mfsd2 / ノックアウトマウス |
|---|
| Outline of Final Research Achievements |
We demonstrated that rat Mfsd2 plays a role in body growth. These result suggest that Mfsd2 influence nutrition and hormones. However, there was no difference between KO mouse and WT mouse in levels of blood IGF-1 or sex hormones. No difference was found histologically in tissues of the liver, white adipose tissue or muscle. Nor could any significant difference be found in the expression of metabolism-related genes (G6PDase and PEKCK) or fatty acid beta-oxidation enzymes (CPT1a, Acad, Acox1).
|
| Free Research Field |
医歯薬学
|
