• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Analysis of vaccine-mediated immune induction in Mucopolysaccharidosis-specific iPS cells

Research Project

  • PDF
Project/Area Number 25461558
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOsaka City University

Principal Investigator

Tokuhara Daisuke  大阪市立大学, 大学院医学研究科, 講師 (60448751)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsワクチン / 自然免疫 / 小児 / 感染症 / 単球 / サイトカイン
Outline of Final Research Achievements

When Toll-like receptor (TLR)-mediated innate immune response was compared between Mucopolysaccharidosis (MPS)-specific cells and control iPS cells, zymosan or MALP2-mediated cytokine levels were significantly lower in MPS-specific iPS cells-derived dendritic cells compared to control iPS cells-derived dendritic cells. Then, when TLR-mediated innate immune response was compared between healthy neonates and healthy adults, immaturity of TLR-mediated immune response was disclosed to depend on cell types and TLR types in neonates, however zymosan provided comparable immune response between neonates and adults. Therefore, vaccine using zymosan as an adjuvant may play a key role in vaccine development for MPS children.

Free Research Field

粘膜免疫学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi