2016 Fiscal Year Final Research Report
Role of Arcadlin on synaptic plasticity
| Project/Area Number |
25461563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 脳・神経 / 行動学 / 神経科学 / Arcadlin / arcadlin knockout mice / epileptic seizure / Morris water maze / kindling |
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| Outline of Final Research Achievements |
We investigated the role of Arcadlin on synaptic plasticity such as epileptic seizure or learning and memory. We found that the development of amygdala kindling was facilitated in arcadlin knockout mice（ko）compared to wild type mice (wt). In addition, the day until 5 repetitive general convulsion was significantly less in ko. The walking velocity was significantly higher and the distance was significantly longer in ko compared to wt in open field test. The latency to enter the light area first from the dark area was significantly shorter in ko compared to wt in dark-light test. In Morris water maze test there was a significant delay in the latency to reach the goal plat form in young ko compared to wt.
Our study revealed that Arcadlin suppresses development of epileptic seizure and facilitates learning and memory in an age-dependent manner.
Furthermore, Arcadlin might have a role on attention deficit hyperactivity disorder (ADHD).
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| Free Research Field |
脳科学
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