2015 Fiscal Year Final Research Report
Development of diagnostic biomarker of mitochondrial disorders
| Project/Area Number |
25461571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YATSUGA Shuichi 久留米大学, 医学部小児科, 助教 (10454919)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ミトコンドリア脳筋症 / バイオマーカー / 感度・特異度 / GDF15 / 診断アルゴリズム / 体外診断薬開発 |
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| Outline of Final Research Achievements |
Mitochondrial disorders, an intractable genetic disease, is the disorders who have not produce enough ATP generation. Using rho zero cellular model, we have identified GDF15, which is the most useful and reliable mitochondrial biomarker for diagnosis and monitor the clinical progression in mitochondrial disorders. We have been developing the testing device of GDF15 and doing the clinical trial for application for diagnostic device in Japan.
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| Free Research Field |
ミトコンドリア病
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