2015 Fiscal Year Final Research Report
Development of epicutaneous immunotherapy for food allergy using indution of regulatory T cells
| Project/Area Number |
25461583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 食物アレルギー / 経皮感作 / アトピー性皮膚炎 / IgE |
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| Outline of Final Research Achievements |
We established a mouse model, in which after epicutaneous sensitization, allergic diarrhea was induced by initial oral ingestion of an antigen and thereby we examined effects of skin lesion on the induced symptoms of food allergy. After development of food allergy caused by epicutaneous sensitization, continuous exacerbation of the skin lesion deteriorated the oral antigen induced allergic symptoms. Epicutaneous application of steroid improved the skin lesions, leading to suppression of food allergy symptoms. Infants with atopic dermatitis often comorbid with food allergy. Our results suggest that after epicutaneous sensitization, even initial intake of food could induce allergic symptoms and that control of skin lesion is important to prevent the development of food allergy symptoms as well as food elimination.
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| Free Research Field |
アレルギー
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