2015 Fiscal Year Final Research Report
Endosomal sorting signal of cytokine receptors and its single nucleotide polymorphism in allergy disease
| Project/Area Number |
25461586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Katsuhiko 信州大学, 学術研究院医学系, 講師 (80345743)
YOSHINO Kazuhisa 信州大学, 学術研究院医学系, 助教 (40551859)
AMANO Yuji 信州大学, 学術研究院医学系, 助教 (50624681)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | サイトカイン |
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| Outline of Final Research Achievements |
In lymphoid cell, intracellular compartments, which keep the specific substances of the system and exchanges the substances between the compartments, is supported by endosomal sorting. Here, we elucidated endosomal sorting mechanism of interleukin-2 receptor β (IL-2Rβ) and interleukin-4 receptor α (IL-4Rα), and explored single nucleotide polymorphism (SNP) of the receptors in allergy patients. We identified novel SNPs in IL-4Rα gene locus of the patients. On the other hand, the SNP involved in endosomal sorting was not detected in the patients.
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| Free Research Field |
免疫学
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