Function of Insulin-like growth factor in neuroblastoma cell proliferation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: Komada Yoshihiro 三重大学, 学内共同利用施設等, 学長 (80186791)
• Co-Investigator(Kenkyū-buntansha): Toyoda Hidemi 三重大学, 医学(系)研究科(研究院), 助教 (60525327)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経芽腫 / インスリン様成長因子 / 細胞内増殖シグナル

Outline of Final Research Achievements

Insulin-like growth factor receptor (IGF-R) plays an important role on cancer cell proliferation.
It has been shown that neuroblastoma (NB) cells can be categorized into three groups by the patterns of IGF-R pathway response. The IGF-R pathway can be activated by endogenous IGF in group 1 NB cells. Stimulation of IGF-R pathway can be induced by exogenous IGF in group 2 NB cells. Activated IGF-R pathway hardly accelerate the cell proliferation of group 3 NB cells. In addition, IGF-R growth stimulation can be mediated by several different intracellular signal transduction pathways.
These results suggest that the significant heterogeneity of NB cells in IFG-R-mediated cell proliferation response should be taken enough into consideration, when any signal transduction inhibitors are used in the clinical treatment of NB patients.

Free Research Field

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