2015 Fiscal Year Final Research Report
Disease modeling of mosaic CINCA syndrome with iPS cells
| Project/Area Number |
25461591
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
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Principal Investigator |
Saito Megumu 京都大学, iPS細胞研究所, 准教授 (90535486)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | CINCA症候群 / 体細胞モザイク / iPS細胞 |
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| Outline of Final Research Achievements |
Taking advantage of iPS cells from CINCA syndrome patients with somatic mosaicism, we aimed at 1) exploring the pathogenic mechanism of somatic mosaicism, and investigating the function of compounds that might inhibit the activity of NLRP3 inflammasome.As a result, 1) our data suggested that the somatic ontogeny might be tracked using iPS cells, 2) we established a screening system using iPS cell-derived monocytic cells and monocytic cell lines.
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| Free Research Field |
幹細胞生物学
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