2016 Fiscal Year Final Research Report
Elucidation and control of molecular mechanism in WT1 peptide vaccine therapy after allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
25461592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 小児がん / 同種造血細胞移植後 / WT1 / ペプチドワクチン |
|---|
| Outline of Final Research Achievements |
A WT1 peptide vaccine targeting the WT1 protein was developed and clinical research was carried out "Allogeneic Immunotherapy Postoperative Phase 2 Study on Patients With Intractable Pediatric Blood Tumors Using WT1 Vaccine". Registration example 18 cases were analyzed. Among them, 4 out of 7 patients remained in remission in non remission phase transplant group and revealed that it is effective in pediatric hematologic malignancy. We found that WT1 - specific killer T cells were significantly increased by flow cytometry compared with that before inoculation, and that the rate of increase was high in remission surviving cases, and it was clarified that it is useful as a biomarker. I could create a new concept of "maintenance therapy by WT1 vaccination after hematopoietic cell transplantation".
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| Free Research Field |
がん免疫
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