Molecular basis of central neurvous invasion of pediatric leukemia

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Shimane University
• Principal Investigator: FUKDUA SEIJI 島根大学, 医学部, 教授 (30273147)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 急性骨髄性白血病 / 細胞遊走 / 浸潤

Outline of Final Research Achievements

One of the major indicators of poor prognosis in leukemia patients is extramedullary infiltration or dissemination of leukemia cells. In particular, leukemia cell infiltration into the central nervous system is one of the major complications negatively influencing prognosis. However, little is known about the mechanisms responsible for extramedullary dissemination of leukemia cells compared to those responsible for solid tumor metastasis. In the present study, we have identified molecular mechanism responsible for the enhanced chemotaxis towards chemokine CXCL12 that is induced by the Internal Tandem Duplication mutation of FLT3 gene (FLT3/ITD) associated with extremely poor prognosis. We subsequently investigated if antagonizing this particular molecular mechanism can be utilized for the treatment to block the unnecessary migration of the hematopoietic cells with FLT3/ITD.

Free Research Field

小児科学