2015 Fiscal Year Final Research Report
Demonstration of global coagulation assays and the suppression mechanism about acquired coagulation disorders
| Project/Area Number |
25461605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGAMI Keiji 奈良県立医科大学, 医学部, 准教授 (50326328)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 後天性凝固異常症 / 凝固因子 / インヒビター |
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| Outline of Final Research Achievements |
Acquired coagulation factor inhibitors occur rarely, but may develop spontaneously haemorrhage symptoms as autoantibodies in previously normal individuals. However, the suppression mechanism is not clear. In the existence group, the decrease, no group of procoagulant activities elucidated activation protein C-resistant presence in the presence or absence of haemorrhage symptoms in acquired factor V inhibitor. Also, the coagulation function rating system to grasp clinical condition is essential. We established coagulation and fibrinolysis ability evaluation by Thrombin/Plasmin, quickly VWF measurement by the new diagnostic methods. A approach using clot waveform analysis provided useful means of differentiating coagulation defects in inhibitor patients with a prolonged aPTT.
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| Free Research Field |
血栓止血
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