Studies on the role of M2 type-activated macrophage in the progression of chronic kidney diseases (CKD).

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461618
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Niigata University
• Principal Investigator: Ikezumi Yohei 新潟大学, 医歯学総合病院, 講師 (70361897)
• Co-Investigator(Kenkyū-buntansha): Kawachi Hiroshi 新潟大学, 医歯学系, 教授 (60242400) ; Suzuki Toshiaki 新潟大学, 医歯学総合病院, 助教 (50419305)
• Co-Investigator(Renkei-kenkyūsha): Narita Ichiei 新潟大学, 医歯学系, 教授 (20272817)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: M2型活性化マクロファージ / 慢性腎臓病 / 尿細管間質線維化 / 糸球体硬化

Outline of Final Research Achievements

The role of alternatively activated macrophages (M2) in progression of chronic kidney disease was examined by immunohistological staining of biopsy specimen and in vitro studies using human monocyte-derived macrophage.
We found that M2 exerted an anti-inflammatory effect at the site of inflamed-tissue, while playing a role in the progression of chronic lesions. In addition, we found that steroid, a widely used drug in the treatment of kidney diseases, could augment the chronic lesion. Combined treatment with antimetabolite could counteract the steroid-induced M2 activation, and might be useful for the treatment of CKD.

Free Research Field

小児腎臓病学