2015 Fiscal Year Final Research Report
Investigation of mechanism for young children of obstructive sleep apnea syndrome to be lean
| Project/Area Number |
25461619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 小児 / 睡眠時無呼吸症候群 / 睡眠呼吸障害 / 扁桃肥大 / アデノイド増殖 / 扁桃摘出術 / レプチン / IGF-1 |
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| Outline of Final Research Achievements |
The BMI percentiles of young patients with obstructive sleep apnea syndrome (OSAS) was lower than the age- and gender-specific reference values, but increased rapidly after treatment. Thus, OSAS seems to exert pathophysiological effects on a thin physique. The mechanism of these effects could be related to the changes in the autonomic nervous system during sleep, as evidenced by the markedly elevated morning urinary cortisol levels and morning blood pressure observed in severe OSAS patients. In contrast, no significant differences in the levels of appetite-related hormones such as leptin and ghrelin and growth factors such as insulin-like growth factor 1 were observed between young patients with and without OSAS or between those with OSAS before and after adenotonsillectomy. Therefore, the above-mentioned effects are less likely to be related to endocrinological changes and are more likely to be related to the changes in the autonomic nervous system during sleep.
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| Free Research Field |
小児の睡眠呼吸障害
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