2015 Fiscal Year Final Research Report
The effect of CD28 signal in podocyte injury
| Project/Area Number |
25461624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Akihiro 宮崎大学, 医学部, 医員 (30628889)
FUJIMOTO Shouichi 宮崎大学, 医学部, 教授 (80173467)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ポドサイト / CD８０ / CD２８ |
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| Outline of Final Research Achievements |
We investigate that effect of CD80-CD28 signal in podocyte injury. Both of CD80 and CD28 expression were upregulated by podocyte injury stimuli such as angiotensin 2 and polyI;C. Immunoprecipitation analysis showed that CD80 combined with CD28. Activating CD28 signal by anti-CD28 antibody induced decreasing of actin stress fiber in podocyte. However we could not fined the molecules, which were activated by CD28 signal.
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| Free Research Field |
小児腎臓
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