Occult HBV infection in children

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya City University
• Principal Investigator: ITO KOICHI 名古屋市立大学, 医学(系)研究科(研究院), 助教 (00444977)
• Co-Investigator(Kenkyū-buntansha): SUGIURA Tokio 名古屋市立大学, 医学研究科, 講師 (10381881)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Yasuhito 名古屋市立大学, 医学研究科, 教授 (90336694)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HBV / 小児 / 母子感染 / ワクチン

Outline of Final Research Achievements

【Background/Aims】Presence of occult HBV infection in HBV vaccinated children remains largely unknown. The aim of　this study was to investigate the prevalence of occult HBV infection among HBV vaccinated children in Japan.【Methods】HBsAg negative sera from vaccinated children were enrolled. The titers of HBV DNA were determined by Real-time PCR.【Results】Anti-HBc was detected in 45 (67%) children. Among these,26 subjects were analyzed by Real-time PCR. Seven out of 26 (27%) subjects were HBV DNA positive. The titers of HBV DNA were so low that the results need to be interpreted carefully. To clarify the precise prevalence of occult HBV infection in children, further study is needed.

Free Research Field

肝臓