2015 Fiscal Year Final Research Report
Pathophysiology of pediatric heart failure with preserved ejection fraction
| Project/Area Number |
25461630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 心不全 / 駆出率 / 小児 / stiffness / relaxation / elastance / reserve / Fontan |
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| Outline of Final Research Achievements |
This study has clarified the detail hemodynamics in pediatric HFpEF. Those include ventricular systolic, diastolic, and arterial stiffness at rest. Furthermore, those characteristics are associated with diastolic and catecholamic reserves, and coronary supply-demand balance.
Fontan circulation has higher diastolic and arterial stiffness, which are similar to pediatric HFpEF. However, there is marked differences in the ventricular filling pressure: high filling pressure in HFpEF and low filling pressure in good Fontan. We also clarified the good correlations between peripheral venous pressure and central venous pressure, and between arm equilibrium pressure and mean circulatory filling pressure in Fontan patients.
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| Free Research Field |
小児循環器
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