2015 Fiscal Year Final Research Report
Theraputic strategy for for idiopathic nephrotic syndrome targetted against molecules expressed on podocytes
| Project/Area Number |
25461634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 微小変化型ネフローゼ症候群 / ポドサイト / エンドセリン / エンドセリン受容体拮抗薬 / アンブリセンタン |
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| Outline of Final Research Achievements |
The abnormal expression of podocyte-related molecules has been attracting attention with respect to the pathogenesis of minimal change nephrotic syndrome (MCNS). Even in the case of endothelin (ET), which has a potent vasoconstrictor effect, it has become clear that the receptor is expressed in the podocytes, and the possibility of ET causing proteinuria and structural changes in podocytes has been reported. Therefore, the possibility of using ET antagonistic drug was investigated using rat models. According to the results, the proteinuria in the treatment group was lower than the significant proteinuria in the untreated group. Upon electron microscope observation, the characteristic foot process fusion of podocytes was found in the untreated group, but not in the treatment group. The results suggested that the ETA antagonists directly act on podocytes to exhibit an anti-proteinuric effect, and it was thought to have potential as a therapeutic agent for MCNS.
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| Free Research Field |
医歯薬学
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