A pro-resolving lipid mediator effectively restores bleomycin-induced alveolar maturation arrest in neonatal rats

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Osaka Medical College
• Principal Investigator: Ogihara Tohru 大阪医科大学, 医学部, 准教授 (00211128)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: BPD / resolvin / bleomycin

Outline of Final Research Achievements

It has long been thought that the resolution of inflammation is a passive process associated with a shift in leukocyte population, neutrophils to macrophages, and a clearance of proinflammatory cytokines. Recently, it has been gradually revealed that the resolution of inflammation is an active process governed by several pro-resolving mediators such as fatty acid derivatives including lipoxine, resolvin, and protectin. The precise pathogenesis of BPD is not clearly understood, however, prolonged, non-resolving inflammation may be deeply correlated to the onset and severity of BPD. We hypothesized that the administration of pro-resolving lipid mediators may induce early termination of inflammation and mitigate the severity of BPD. In this study, we used a model of bleomycin-induced BPD in neonatal rats and confirmed that resolvin, one of the pro-resolving lipid mediators, effectively prevented alveolar maturation arrest.

Free Research Field

新生児呼吸障害