Transplantation of rat umbilical cord blood cells for neonatal hypoxic-ischemic brain injury.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461659
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: NAKANISHI KEIKO 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (50280813)
• Research Collaborator: SATO YOSHIAKI 名古屋大学, 医学部附属病院・総合周産母子医療センター・新生児科, 講師 ; ITO MIHARU 名古屋大学, 医学部附属病院・総合周産母子医療センター・新生児科, 特任助教 ; HIGASHI YUJIRO 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 部長 ; MIZUTANI YUKA 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 助手 ; HIRAKAWA AKIHIRO 名古屋大学, 医学部附属病院・先端医療・臨床研究支援センター, 講師
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 臍帯血幹細胞 / 新生児低酸素性虚血性脳症

Outline of Final Research Achievements

Mononuclear cells isolated from rat umbilical cord blood were expanded (stem cell enriched-umbilical cord blood cells; SCE-UCBCs) and they were administered intraperitoneally to neonatal hypoxic-ischemic encephalopathy (HIE) model of rats. Administration of SCE-UCBCs increased the residual brain volume and decreased the accumulation of activated microglia to lesion site. These results indicate that UCBCs could ameliorate HI injury, possibly through an endogenous response.

Free Research Field

神経科学、新生児学