Elucidating roles of plasmin in blister formation of bullous pemphigoid

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461661
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hokkaido University
• Principal Investigator: Nakamura Hideki 北海道大学, 医学(系)研究科(研究院), 助手 (60435956)
• Co-Investigator(Kenkyū-buntansha): NISHIE Wataru 北海道大学, 大学院医学研究科, 准教授 (20443955) ; NATSUGA Ken 北海道大学, 大学病院, 助教 (70645457) ; SHIMIZU Hiroshi 北海道大学, 大学院医学研究科, 教授 (00146672)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 水疱性類天疱瘡 / プラスミン / 17型コラーゲン

Outline of Final Research Achievements

Bullous pemphigoid (BP) is an autoimmune blistering disease. The aim of this study is to address the pathogenic roles of plasmin, a protease present in blister fluids of BP, which is known to cleave COL17. We first identified cleavage sites of COL17 by plasmin, and based on this data, cleavage site-specific antibodies were generated. The antibodies revealed that COL17 is actually cleaved by plasmin in lesional skin of certain numbers of BP patients.

Free Research Field

皮膚科学