2015 Fiscal Year Final Research Report
The mechanisms of skin fibrosis and calcification in nephrogenic systemic fibrosis
| Project/Area Number |
25461662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Gunma University |
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Principal Investigator |
Ishikawa Osamu 群馬大学, 医学(系)研究科(研究院), 教授 (90168188)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腎性全身性線維症 / 皮膚線維化 / ガドリニウム / 間葉系幹細胞 / エンドセリン |
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| Outline of Final Research Achievements |
Nephrogenic systemic fibrosis (NSF) is characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. It is considered that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. However, the causative role of Gd and the mechanism of Gd-induced fibrosis and calcification in NSF are unknown.We conclude that Gd induces proliferation and calcification of human mesenchymal stem cells via enhancement of endothelin-1/endothelin receptor signalling. Our results contribute to understand the pathogenesis of NSF.
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| Free Research Field |
皮膚線維化
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