An establishment of novel treatment based for the pathogenesis of untreated allergic skin diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461665
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yokozeki Hiroo 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90210608)
• Co-Investigator(Kenkyū-buntansha): IGAWA Ken 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00372441)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 好塩基球 / 痒疹 / TH2サイトカイン / M2マクロファージ / STAT6 / IgE / プロテアーゼ / 蕁麻疹

Outline of Final Research Achievements

Prurigo nodularis, prurigo type atopic dermatitis is a chronic and untreated diseases. In order to investigate a mechanism for prurigo reaction, we have been established a mouse model for prurigo by using a TNP-IgE transgenic mice (Immunity, 2005, Mukai K, J Immunol,2015, Hasimoto T et al). And we clarify that MT play a major role in the induction of IL-4 in basophils.

Free Research Field

皮膚科学