the pathogenic mechanisms of EGFR inhibitor-induced rash and establishment of system for constructing medical treatment

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Shinshu University
• Principal Investigator: UHARA Hisashi 信州大学, 学術研究院医学系, 准教授 (40201355)
• Co-Investigator(Kenkyū-buntansha): ASHIDA Atsuko 信州大学, 学術研究院医学系, 助教 (00596786) ; OKUYAMA Ryuhei 信州大学, 学術研究院医学系, 教授 (80292332)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: EGFR阻害剤 / ざ瘡様皮疹 / 脂腺細胞 / SEB-1 / PPARγ / NFkappaB / COX-2

Outline of Final Research Achievements

We investigated the pathogenic mechanisms of EGFR inhibitor-induced papulopustular rash development, using cultured human sebocytes, SEB-1. Blockade of EGFR led to TNFα induction, which was associated with sebaceous differentiation. EGFR inhibitor-induced TNFα　expression was involves with PPARγ, COX-2 and NFκB; thus, inhibition of these molecules may attenuate inflammation of papulopustular rash.

Free Research Field

皮膚科学