2015 Fiscal Year Final Research Report
The pathogenesis of palmoplantar pustulosis and the eccrine sweat innate immune system failure
| Project/Area Number |
25461670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Shirakata Yuji 愛媛大学, 医学部附属病院, 准教授
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 掌蹠膿疱症 / 抗菌ペプチド |
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| Outline of Final Research Achievements |
Based on the reported finding that eccrine gland of the lesion could be involved in the pathogenesis of palmoplantar pustulosis (PPP), we searched suspected materials which contributed to the pathogenesis of PPP in lesion vesicles. As one of the candidates, hCAP18/LL37 expression in the vesicles was nominated, and we showed that it contributed to subsequent lesion inflammation with upregulation of inflammatory cytokines. According to this finding, PPP could be regarded as a disease which was caused by abnormal antimicrobial expression, innate immune system failure.
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| Free Research Field |
皮膚科学
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