2015 Fiscal Year Final Research Report
Wound healing in focusing extracellular matrices
| Project/Area Number |
25461673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagasaki University |
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Principal Investigator |
UTANI Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (10292707)
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| Co-Investigator(Kenkyū-buntansha) |
KUWATSUKA Yutaka 長崎大学, 医歯薬学総合研究科(医学系), 助教 (90437864)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細胞外マトリックス / 創傷治癒 / バーシカン / トレース / トランスジェニックマウス |
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| Outline of Final Research Achievements |
In this study, we focused on a versican (VCAN), a proteoglycan that has chondroitin sulfates chains as glycosaminoglycans. We immunohistochemically found its transient expression in the wound during 3-7 days after wounding on the mouse skin. Furthermore, we made VCAN-promoter-Cre transgenic mouse and obtained VCAN-Cre;ROSA26R mice. Trace experiments with this moice revealed X-gal staining-positive cells were appeared in the wound during 3 to 5 days after wounding. Based on these findings, transient presence of VCAN and its producing cells in the wound may have an essential role for cell migration other than a role as structural components.
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| Free Research Field |
皮膚科学
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