Evaluation of functional roles of podoplanin in skin

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Asai Jun 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50438222)
• Co-Investigator(Kenkyū-buntansha): KATOH Norito 京都府立医科大学, 医学研究科, 教授 (30244578) ; TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
• Co-Investigator(Renkei-kenkyūsha): HIRAKAWA Satoshi 浜松医科大学, 医学部, 准教授 (50419511)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 創傷治癒 / 表皮細胞 / ポドプラニン

Outline of Final Research Achievements

In this study, we evaluated the functional roles of podoplanin in keratinocytes in normal and pathological conditions, especially wound healing and malignant tumor. In wound healing, podoplanin upregulation was observed at the keratinocytes at wound edge. Podoplanin mediated keratinocytes proliferation and motility which resulted in accelerating wound healing. In Extramammary Paget's disease, podoplanin expression was observed at the site of invasion. Podoplanin expression on keratinocytes could predict agressive behavior of Extramammary Paget's disease.

Free Research Field

皮膚腫瘍学、皮膚外科学