2015 Fiscal Year Final Research Report
The roles of TLR2 and TLR4 in mouse imiquimod-induced psoriasis model
| Project/Area Number |
25461684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | TLR / 乾癬 / マウスモデル |
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| Outline of Final Research Achievements |
Imiquimod-induced psoriasis-like dermatitis was exacerbated in TLR2-deficient (TLR2(-/-)) mice compared to wild type (WT) mice, while it was comparable between TLR4-deficient and WT groups. In the lesional skin on day 2, the expression levels of Th1 cytokines were higher in TLR2(-/-) mice than those in WT mice. On the other hand, the expression of Th17 cytokines and Foxp3 was decreased in TLR2(-/-) mice compared to WT mice. In the skin draining lymph node, the expression of TGF-beta and the number of CD4(+)Foxp3(+) cells was decreased in TLR2(-/-) mice relative to WT mice on the day 2 of imiquimod application. Taken together, elevated Th1 cytokines and suppression of regulatory T cells may account for the exacerbation of imiquimod-induced psoriasis dermatitis observed in TLR2(-/-).
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| Free Research Field |
皮膚免疫
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